Capsule Corps. plans to develop a new form of technology untouched in the field of bioengineering.

The symptoms of many long-term diseases cannot be remedied because of difficulties in precisely regulating the concentration of a target molecule in a patient’s body. Diabetes, for example, requires consistent injections of insulin. Though strict dietary and injection rules are enforced, there are usually discrepancies between the insulin concentration needed at the moment and the common dose of injection. This causes hypoglycemia (low glucose concentration in blood), increasing risks for high blood pressure and heart disease.

We will serve this unmet need for a precise input of molecules in the body in an noninvasive manner. This is through placing probiotics, serviceable bacteria (e.g. the bacteria in yogurt) in the patients' body. In order to preserve the gut microbiota, avoid rejection and secure safe removal, the probiotics are sealed inside a capsule-like device with a semi-per...
Capsule Corps. plans to develop a new form of technology untouched in the field of bioengineering.

The symptoms of many long-term diseases cannot be remedied because of difficulties in precisely regulating the concentration of a target molecule in a patient’s body. Diabetes, for example, requires consistent injections of insulin. Though strict dietary and injection rules are enforced, there are usually discrepancies between the insulin concentration needed at the moment and the common dose of injection. This causes hypoglycemia (low glucose concentration in blood), increasing risks for high blood pressure and heart disease.

We will serve this unmet need for a precise input of molecules in the body in an noninvasive manner. This is through placing probiotics, serviceable bacteria (e.g. the bacteria in yogurt) in the patients' body. In order to preserve the gut microbiota, avoid rejection and secure safe removal, the probiotics are sealed inside a capsule-like device with a semi-permeable membrane.

This is a very new concept and the potential of such capsules are very promising in treating long-term disease. Earliest papers that we could track range back to just May 2018, when a research group from MIT successfully engineered an animal-compatible device which contains heme-sensing bacteria. The device is placed in pigs, and if there is an internal bleeding, the bacteria inside the device would glow; the inner electronics would then detect the photosignal, and alarm the pig’s owner. Our idea takes a step above this research, and hope to enclose engineered probiotics inside a human-compatible device, in order to safely produce regulated amount of target molecules in the body, thus largely enhance the molecule delivery accuracy.

Additional to the huge potential market of long-term disease and the fact that we are the forerunner in this field, feasibility is another advantage we have that makes Capsule Corps stands out from others. We can limit our R&D cost as we only need to develop the device, and we don’t need to engineer the probiotics from scratch. There is a matured streamline for genetically engineering bacteria that produces certain molecules. Synthetic insulin in diabetes doses, for instance, is produced by common bacterium engineered with an inserted human gene. Bacterium are natural cell factories: they could sense the outer environment, release molecules that we want, and be sustainable and replicating.
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Sophia Zhang
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Sophia Zhang CEO Hi, I am Sophia! I'm an undergrad majoring in genetic engineering, and economics + computer science.