CropVax technology facilitates the development and delivery of novel crop protection products based on RNAi technology. Our system utilises a natural platform to encapsulate RNAi in vivo and efficiently deliver it into crops to act as a pesticide. CropVax provides solutions to two key areas of market opportunity presented by limitations of classical control methods. (1) Chemical sprays and resistant varieties are time consuming to develop and expensive to bring to market and (2) Classical protection methods offer limited treatment against viruses and fungal pathogens.

Problems – Chemical sprays and modified/selectively bread varieties

A) Time consuming - New products take 10 years to develop and bring to market.
B) Expensive - New products cost upwards of £200m to develop and bring to market.
C) New products become ineffective within a few years of use due to resistance developing in the target pathogen.
D) Limited protective treatments available to target viral and fungal pathog...
CropVax technology facilitates the development and delivery of novel crop protection products based on RNAi technology. Our system utilises a natural platform to encapsulate RNAi in vivo and efficiently deliver it into crops to act as a pesticide. CropVax provides solutions to two key areas of market opportunity presented by limitations of classical control methods. (1) Chemical sprays and resistant varieties are time consuming to develop and expensive to bring to market and (2) Classical protection methods offer limited treatment against viruses and fungal pathogens.

Problems – Chemical sprays and modified/selectively bread varieties

A) Time consuming - New products take 10 years to develop and bring to market.
B) Expensive - New products cost upwards of £200m to develop and bring to market.
C) New products become ineffective within a few years of use due to resistance developing in the target pathogen.
D) Limited protective treatments available to target viral and fungal pathogens.
E) Chemical sprays can be indiscriminate and impact neighbouring flora and fauna.
F) Chemical products can accumulate in the water system as there are often limited degradation mechanism in nature
G) Majority do not penetrate inside the plant: they get washed off by wind and rain and only offer protection for 7-15 days.

Solution - CropVax

A) Rapid - CropVax products can be developed in months. Novel products can be created with routine molecular biology manipulation.
B) Cheaper – Delivery platform remains constant. New product development requires only the evaluation of target RNAi sequences against the specific pathogen, not the platform.
C) We drastically decrease chances of resistance development by targeting multiple regions within the pathogen simultaneously.
D) Protect against challenging to control pathogens such as viruses or fungi.
E) Specific attack - CropVax products do not harm the native flora and fauna. RNAi technology allows the specific targeting of the pathogens. We are stimulating the plants natural defense mechanisms to specifically target pathogens.
F) Biodegradable - CropVax protective shell and RNAi payload are biomolecules and therefore can be degraded and they don't accumulate in the water systems.
G) Penetration inside the plant cell: RNAi stays inside the plant cell and does not get washed off. Protection is offered for at least 20-30 days.
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Employees

Aleix Gorchs Rovira
Admin
Aleix Gorchs Rovira PhD in Molecular Biology at the University of Cambridge. Interested in the evolution of pesticides and the challenges that we are facing